Comparison of blood and cold cardioplegia: Normacor, Calafiore and Custodiol
Purpose of the study
Comparison of the efficacy and safety of blood and cold cardioplegia techniques using the solution Normacor, the Calafiore method, and Custodiol solution as examples.
Spontaneous restoration of heart rhythm was observed more frequently in groups with blood cardioplegia
In the Normacor group, spontaneous cardiac recovery was observed in 93% of patients, in the Calafiore group - in 87%, in the Custodiol group - in 74%.
The time to cardiac arrest was significantly lower in the blood cardioplegia groups
The time of cardiac arrest in the Normacor group was 39±16 sec, in the Calafiore group - 33±11 sec, in the Custodiol group - 177±23 sec.
Cardiac arrest through asystole was more frequently observed with the use of blood cardioplegia
Cardiac arrest due to asystole was observed in 89% of patients in the Normacor group, in 91% in the Calafiore group, and in 57% in the Custodiol group.
Rhythm restoration occurred faster in groups with blood cardioplegia
The rhythm recovery time in the Normacor group was 95±11 sec, in the Calafiore group - 101±15 sec, in the Custodiol group - 224±57 sec.
The duration of inotropic therapy was significantly shorter when using blood cardioplegia
Duration of inotropic therapy: Normacor - 6.1±1.9 h, Calafiore - 5.7±2.9 h, Custodiol - 19±7 h. (p<0.05).
Atrial fibrillation was observed less frequently with the use of blood cardioplegia
Fibrillation was observed in 11.7% of patients in the Normacor group, in 15% in the Calafiore group, and in 23.8% in the Custodiol group (p=0.05).
Conclusion
Blood cardioplegia based on the Normacor solution is not inferior to the Calafiore method in terms of cardioprotective effectiveness, and in a number of parameters exceeds the effectiveness of myocardial protection using the Custodiol (HTK) solution.
