Observational studyPublication in the Journal of Cardiothoracic and Vascular Anesthesia

Evaluation of the effectiveness of blood cardioplegic solution (Normacor) and cardioplegia using the Calafiore method in cardiac surgery

Normacor is comparable to the Calafiore method for myocardial protection in CABG
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Clinical center
First Moscow State Medical University named after I.M. Sechenov, Ministry of Health of Russia (Moscow)
Study design
Comparative clinical study
Sample
56 patients
Normacor group
28 patients
Calafiore group
28 patients
Types of operations
CABG for myocardial revascularization

Purpose of the study

Evaluation of the efficacy and safety of the normothermic blood solution for cardioplegia Normacor in comparison with cardioplegia using the Calafiore method during CABG.

1

Postoperative left ventricular ejection fraction values showed insignificant differences between groups

In the Normacor group, the postoperative left ventricular ejection fraction was 0.45±0.03, in the Calafiore group - 0.43±0.04.

Postoperative LV ejection fraction
0,45±0,03
Normacor
0,43±0,04
Calafiore
2

The need for inotropic support did not differ significantly between groups

The frequency of use of inotropic drugs in the Normacor group (23%) was similar to that in the Calafiore group (29%).

Frequency of use of inotropic support
23%
Normacor
29%
Calafiore
3

The incidence of postoperative atrial fibrillation was comparable in both groups

The incidence of postoperative atrial fibrillation in the Normacor group was 13%, in the Calafiore group - 15%.

Postoperative atrial fibrillation
13%
Normacor
15%
Calafiore
4

The duration of heart rhythm recovery was similar in both groups

The time of heart rhythm recovery did not differ significantly in the Normacor group (101±13 sec.) and in the Calafiore group (96±23.7 sec.).

Rhythm recovery time (sec.)
101±13,0
Normacor
96±23,7
Calafiore

Conclusion

Cardioplegia with Normacor solution provides effective myocardial protection during CABG surgery and is comparable to cardioplegia using the Calafiore method, known for its cardioprotective properties.

JSC "CARDIOSYSTEMPHARMA"
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